Are you going to drive your own vehicle or will you hire one? Driving a car with four-wheel or all-wheel drive is recommended for road travels in the winter.
You should absolutely plan your route in advance and be aware that wintertime road conditions can vary greatly from those encountered during other seasons.
Planning for pit stops is essential, as is researching your route and the weather. Breaking up your driving time with visits to Pilot Flying J is a great way to relax and take a break.